USB pointing devices do not work in Safe Mode

After you try to start your computer in Safe Mode, your computer may not respond to any keyboard commands, or you may receive an error message such as "Windows did not detect a mouse attached to a computer,You can safely attach a serial mouse now". The problem occurs if you are using a USB keyboard or mouse, But your system BIOS does not support USB devices in the real mode. Windows does not support the use of a USB keyboard or mouse in Safe Mode or in real mode unless the computers BIOS supports these devices. To work around this problem, use a standard keyboard or mouse instead of a USB keyboard or mouse. To correct the trouble permanently, upgrade the motherboards BIOS to a version that provides real mode USB support.